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-synuclein, that's a main component of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, that's an E3 ubiquitin ligase and triggers endoplasmic reticulum (ER) worry, advise that dysfunction of the intracellular proteinase units, which include ubiquitin-proteasome method or lysosomal method, which gets rid of avoidable harmful protein
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